NEURODEGENERATION相关论文
Most people associate the enzyme telomerase with its role in maintaining telomeres, which is its best-known canonical ro......
The degeneration of nerve fibres following injury was first described by Augustus Waller over 170 years ago. Initially a......
Inflammatory responses,including glial cell activation and peripheral immune cell infiltration,are involved in the patho......
Polysaccharides are macromolecular complexes that have various biological activities.In vivo and in vitro studies have s......
The incidence of neurodegenerative diseases is increasing due to changing age demographics and the incidence of sports-r......
Alzheimer\'s disease and Parkinson\'s disease are two of the most prevalent and disa-bling neurodegenerative disease......
Glaucoma, a progressive age-related optic neuropathy characterized by the death of retinal ganglion cells, is the most c......
Parkinson\'s disease, the second most prevalent neurodegenerative disorder worldwide, is characterized by a progressiv......
Protein synthesis modulation as a therapeutic approach for amyotrophic lateral sclerosis and frontot
Protein synthesis is essential for cells to perform life metabolic processes. Pathological alterations of protein conten......
Systemic epigallocatechin gallate protects against retinal degeneration and hepatic oxidative stress
Retinitis pigmentosa (RP) is a group of inherited retinal disorders that lead to photoreceptor loss. RP has been reporte......
Neurodegenerative disease etiology is still unclear, but different contributing factors,such as lifestyle and genetic fa......
A major feature of neurodegeneration is disruption of central nervous system homeostasis, during which microglia play di......
Astrocytes are integral components of the central nervous system, where they are involved in numerous functions critical......
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Radio Electric Asymmetric Conveyer Technology Modulates Neuroinflammation in a Mouse Model of Neurod
In this study,the effects of Radio Electric Asymmetric Conveyer (REAC),a non-invasive physical treatment,on neuroinflamm......
The complex spatial and temporal organization of neural activity in the brain is important for informationprocessing tha......
Neuroprotective effects after Brain Extracellular matrix implantation into surgical brain of a TBI m
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Minocycline reduces neuroinflammation but does not ameliorate neuron loss in a mouse model of neurod
Minocycline is a broad-spectrum tetracycline antibiotic.A number of preclinical studies have shown that minocycline exhi......
Objective Parkinsons disease (PD) and dementia with Lewy bodies (DLB) are characterized by the accumulation of abnormal ......
Huntingtons disease (HD) is an autosomal dominant hereditary disease caused by a trinucleotide repeat mutation in the hu......
Neuronal MCP-1 mediates microglia recruitment and neurodegeneration induced by the mild impairment o
Chemokines are implicated in neuroinflammation of several chronic neurodegenerative disorders.However, the precise role ......
Requirement of Zn for ischemia-induced ubiquitin conjugation and protein aggregation in rat hippocam
The ubiquitin-proteasome system (UPS) is the major degradation pathway for intracellular proteins.The impairment and/or ......
Although rare,infections of central nervous systems(CNS)often have devastating consequences.The mortality and morbidity ......
Cerebral amyloid angiopathy(CAA)refers to the deposition of β-amyloid(Aβ)peptides in the wall of brain vasculature,com......
Mitochondria play critical role in neuronal function and survival and mitochondrial abnormalities and dysfunction have b......
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Recently,increasing evidence,including ours,suggested that dysfunction of RNA metabolism may play a key role in etiology......
Alzheimers disease is the most common cause of neurodegeneration in the elderly.Since cholinergic deficit and excitatory......
Ataxia-telangiectasia (A-T) is an autosomal recessive disease caused by mutations in the ATM gene.A-T patients are chara......
Aging Related NADPH-Diaphorase Bodies: a noval neurodegenerative structures within the lumbosacralsp
The lower lumbar and sacral spinal cord is important to controlling the function of the large intestine,the pelvic muscl......
Paraquat and MPTP induce alterations in the expression profiles of long noncoding RNAs in the substa
Parkinsons disease (PD) is a common age-related degenerative disease of the central nervous system caused by hereditary,......
Variation in the autophagic beclin-1 (BECN1) has a potential to modify onset of Machado-Joseph disea
Autophagy, as a process of lysosomal-dependent intracellular components degradation, is especially important in disorder......
Blocking neurodegeneration of Alzheimers diseases is global puzzles in medicine.Single blocking either oxidative stress ......
Parkinsons disease and dementia with Lewy bodies are characterized by the accumulation of abnormal α-synuclein and ubiq......
PF11 protects neuronal function from alcohol induced neuroinflammation-oxidative stress in the adult
AIM Pseudoginsenoside-F1 1 (PF11), an ocotillol-type saponin existing in American ginseng, can inhibit the ethanol-induc......
Distinct Rab7-related Endosomal–Autophagic–Lysosomal Dysregulation Observed in Cortex and Hippocampu
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Parkinson\'s disease (PD) is a chronic progressive neurodegenerative disease.It results from the death of dopaminergic......
Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammati
Axonal degeneration is one of the key features of neu-rodegenerative disorders.In the canonical view,axonal degeneration......
Eukaryotes have evolved a variety of mRNA surveillance mechanisms to detect and degrade aberrant mRNAs with potential de......
The regulation of gene expression in brain vicissitudes during aging is still not much known and explored. Differential ......
Intracellular accumulation of tau protein,low energy metabolism and mitochondrial dysfunction are core features in t......
Alzheimers disease is the most common cause of dementia in the elderly.Since cholinergic deficit and excitatory amin......
Mitoguardin, a novel mitochondrial protein, regulates mitochondria dynamics and neuronal homeostasis
Mitochondria undergo frequent morphologic changes through fission and fusion.Mutations in several core mitochondial ......
Schizophrenia (SCZ) is a complex disease that has been regarded as a neurodevelopmental,synaptic or epigenetic disor......
Vasodegenerative disease, like other so-called diseases of aging, begins decades before it becomes clinically appare......
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Parkinsons disease(PD)is an age-dependent neurodegenerative disease that can be caused by genetic mutations in α-sy......
